Racial wars have torn the U.S. apart, resulting in a post-apocalyptic world. Many small pockets of civilization still exist; from isolated super high-tech fortresses, hidden research labs, or racial groups in walled-in cities — all fighting each other among the more regular population which in many ways resembles the "old west". Jeremiah and his friend Kurdy travel the country, taking odd jobs and getting mixed up in various affairs. Jeremiah, being the more noble of the two, often sticks his neck out to help others, while Kurdy is a more wily, opportunistic scoundrel. Despite its setting, Jeremiah's underlying motif is of hope and the survival of mankind. The storylines carry little from album to album, meaning they can be read individually.