When Reed and Sue decide the family needs to relax, they take Ben, Johnny and the kids on a year-long vacation - through all of infinite time and space! And in the absence of Marvel's First Family, a handpicked substitute FF - Ant-Man, Medusa, She-Hulk and the new Ms. Thing - stand ready to guard the Earth. What could possibly go wrong? As Reed Richards struggles to hide his true motivations and the Future Foundation reacts to their mentors' replacements, Doom the Annihilating Conqueror rises! Can Reed cure the disease that's killing the team?